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Development of a Sprayable Hydrogel-Based Wound Dressing: An In Vitro Model.

Mine Altunbek¹, Mert Gezek^1,2, Maria Eduarda Torres Gouveia¹

¹Department of Chemical Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, MA 01854, USA.

Gels (Basel, Switzerland)

|March 27, 2024

Summary

This study presents a novel sprayable hydrogel wound dressing made from hyaluronic acid and gelatin. The dressing offers self-oxygenation and antibacterial properties, enhancing wound healing potential.

Keywords:

antibacterial activity calcium peroxide self-oxygenation sprayable hydrogel dressing

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Last Updated: Jun 29, 2025

Generation of a Three-dimensional Full Thickness Skin Equivalent and Automated Wounding

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Published on: February 26, 2015

The Polyvinyl Alcohol Sponge Model Implantation

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Published on: April 18, 2012

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Area of Science:

Biomaterials Science
Regenerative Medicine
Wound Healing Technologies

Background:

Hydrogel dressings offer multifunctional wound healing benefits including antibacterial and anti-inflammatory properties.
Sprayable application is crucial for rapid and effective wound coverage.
Naturally derived polymers like hyaluronic acid and gelatin are promising for wound dressing development.

Purpose of the Study:

To develop a sprayable hydrogel wound dressing using hyaluronic acid and gelatin.
To incorporate self-oxygenating and antibacterial functionalities into the hydrogel.
To evaluate the efficacy of the developed dressing for wound healing applications.

Main Methods:

Hyaluronic acid and gelatin were modified with methacrylate groups (HAMA and GelMA) for photocrosslinking.
Sprayability was optimized by varying GelMA concentration (5-15% w/v) with 1% HAMA.
Calcium peroxide was incorporated (0-12 mg/mL) for oxygen release and antibacterial effects.

Main Results:

The composite hydrogels demonstrated sprayability and sustained oxygen release for up to two weeks.
Released oxygen mitigated hypoxia-induced metabolic stress and cell death in fibroblasts.
Calcium peroxide incorporation provided effective antibacterial properties to the hydrogel dressing.

Conclusions:

The developed sprayable hydrogel dressing exhibits potential for advanced wound healing.
Its conformable application and integrated functionalities offer significant advantages.
The self-oxygenating and antibacterial properties contribute to improved wound therapeutic outcomes.