Cardiac Magnetic Resonance Imaging Based Ischemic Injury Pattern in Patients with Acute Myocardial Infarction Sensu Left Ventricular Global Systolic Function
Related Experiment Video
Updated: Jul 6, 2026
Myocardial Infarction and Functional Outcome Assessment in Pigs
Published on: April 25, 2014
Lyudmila Salyamova1, Valentin Oleynikov1, Natalia Donetskaya2
1Therapy Department, Penza State University, 440026 Penza, Russia.
Insights
Factors like male gender and longer time to treatment impact left ventricular systolic function after myocardial infarction. Cardiac MRI and lab tests help identify these risks in ST-elevation myocardial infarction patients.
Area of Science:
- Cardiology
- Medical Imaging
- Biochemistry
Background:
- ST-segment elevation myocardial infarction (STEMI) can impair left ventricular (LV) global systolic function post-revascularization.
- Assessing LV function is crucial for patient outcomes and guiding treatment strategies.
Purpose of the Study:
- To identify factors associated with decreased LV global systolic function in STEMI patients after revascularization.
- To correlate cardiac magnetic resonance imaging (MRI)-derived ischemic injury patterns and laboratory markers with LV systolic function.
Main Methods:
- 109 STEMI patients underwent contrast-enhanced cardiac MRI (1.5 Tesla) 7-10 days post-onset.
- Patients were categorized by left ventricular ejection fraction (LVEF): ≥50% (normal), 40-49% (mildly reduced), and <40% (low).
- Analysis included ischemic injury patterns from MRI and laboratory parameters like natriuretic peptides and troponin I.
Main Results:
- Patients with mildly reduced and low LVEF showed a predominance of ischemic injury pattern parameters compared to those with normal LVEF.
- Identified risk factors for LVEF <50% included male gender, longer time from anginal attack onset to revascularization, coronary artery status, and specific LV parameters.
- Elevated natriuretic peptide and troponin I levels were also associated with decreased LVEF.
Conclusions:
- Cardiac MRI and laboratory markers are valuable in characterizing LV systolic function post-STEMI.
- Key factors influencing reduced LVEF in STEMI patients include demographic, treatment-related, and cardiac injury characteristics.
Abstract:
The purpose of the study was to identify factors characterizing a decrease in LV global systolic function in patients with ST-segment elevation myocardial infarction (STEMI) after revascularization using cardiac magnetic resonance imaging (MRI)-based ischemic injury pattern and laboratory parameters sensu left ventricular global systolic function. A total of 109 STEMI patients were examined. The patients underwent contrast-enhanced cardiac MRI with a 1.5 Tesla GE SIGNA Voyager (GE HealthCare, Chicago, IL, USA) on the 7th-10th days from the onset of the disease. According to cardiac MRI analysis, the patients were divided into the following groups with regard to left ventricular ejection fraction (LVEF) values: Group 1-patients with LVEF ≥ 50%; group 2-patients with mildly reduced LVEF 40-49%; group 3-patients with low LVEF < 40%. A predominance of most parameters of the ischemic injury pattern was noted in patients with mildly reduced and low LVEF versus patient group with LVEF ≥ 50%. Some risk factors for a decrease in LVEF < 50% systolic function in STEMI patients after revascularization were revealed: male gender; time from the onset of the anginal attack to revascularization; coronary artery status; several LV parameters; ischemic injury characteristics; natriuretic peptide and troponin I levels.
Related Concept Videos
01:21Imaging Studies for Cardiovascular System IV: CMRI
01:30Acute Coronary Syndrome III: Diagnostic Studies