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Stresses under Combined Loadings

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Updated: Jun 29, 2025

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves

Published on: August 23, 2011

Shear Stress Quantification in Tissue Engineering Bioreactor Heart Valves: A Computational Approach.

Raj Dave¹, Giulia Luraghi², Leslie Sierad³

¹Department of Mechanical Engineering, Clemson University, Clemson, SC 29634, USA.

Journal of Functional Biomaterials

|March 27, 2024

Summary

This summary is machine-generated.

Engineered heart valves need optimal bioreactor conditions. This study quantifies wall shear stress (WSS) in tissue-engineered heart valves, finding higher WSS near commissures, crucial for tissue development.

Keywords:

CFD FSI TEHV computational model wall shear stress quantification

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Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

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Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Biaxial Mechanical Characterizations of Atrioventricular Heart Valves

Published on: April 9, 2019

Area of Science:

Biomaterials Science
Cardiovascular Engineering
Tissue Engineering

Background:

Tissue-engineered heart valves offer regenerative potential over traditional prostheses.
Cellular maturation in engineered valves requires specific bioreactor conditions.
Mechanical forces, like wall shear stress (WSS), are critical for tissue development but poorly understood in engineered valves.

Purpose of the Study:

To quantify wall shear stress (WSS) in tissue-engineered heart valve scaffolds.
To investigate the impact of varying bioreactor flow rates and valve geometries on WSS.
To provide data for optimizing bioreactor conditions for engineered heart valve development.

Main Methods:

Fluid-structure interaction (FSI) simulations were used to determine valve opening dynamics during systole.
Computational fluid dynamics (CFD) simulations with refined near-wall meshing analyzed WSS.
Simulations were performed across a range of bioreactor flow rates and valve configurations.

Main Results:

WSS distribution, peak, and median values were characterized for different flow rates and valve geometries.
Higher WSS magnitudes were observed in the upper region of the valve near the commissures.
Data provided histograms and regression curves detailing WSS characteristics.

Conclusions:

Bioreactor flow conditions significantly influence WSS experienced by engineered heart valve tissue.
Understanding WSS patterns, particularly higher magnitudes near commissures, is vital for guiding tissue development and scaffold design.
This study provides essential quantitative data for optimizing bioreactor environments to promote functional tissue-engineered heart valve maturation.