Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

162
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
162
Electroconvulsive Therapy01:30

Electroconvulsive Therapy

39
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
39
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

83
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
83
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

166
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
166

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A perspective on neuromechanical biomarkers for neurorehabilitation: towards reliable assessment in research and clinical practice.

Progress in biomedical engineering (Bristol, England)·2026
Same author

The Transdiagnostic Role of Emotion Regulation Difficulties and Repetitive Negative Thinking in Depression, Anxiety, and Their Comorbidity.

Depression and anxiety·2026
Same author

A Novel Minimally Invasive Porcine Model of Functional Tricuspid Regurgitation.

Journal of cardiovascular development and disease·2026
Same author

A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation.

bioRxiv : the preprint server for biology·2026
Same author

Primarily Gasless Robot-Assisted Cholecystectomy in Dogs: A Cadaveric Feasibility Study.

Veterinary sciences·2026
Same author

Establishment of High Channel-Count Packaging in Active Implantable Medical Devices for Neuroprosthesis.

Journal of biomedical materials research. Part B, Applied biomaterials·2026

Related Experiment Video

Updated: Jun 29, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

396

Colonic Electrical Stimulation for Chronic Constipation: A Perspective Review.

Iñaki Ortego-Isasa1, Juan Francisco Ortega-Morán2, Héctor Lozano1

  • 1TECNALIA, Basque Research and Technology Alliance (BRTA), 20009 San Sebastian, Spain.

Biomedicines
|March 28, 2024
PubMed
Summary

Colonic electric stimulation (CES) offers a promising bioelectronic medicine approach for chronic constipation, a widespread condition lacking effective treatments. This review explores CES mechanisms, technical aspects, and animal models for therapeutic development.

Keywords:
bioelectronicscolonic electric stimulation (CES)constipationneural implant

More Related Videos

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

8.5K
Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

1.8K

Related Experiment Videos

Last Updated: Jun 29, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

396
Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa
08:17

Autonomous and Rechargeable Microneurostimulator Endoscopically Implantable into the Submucosa

Published on: September 27, 2018

8.5K
Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

1.8K

Area of Science:

  • Bioelectronic Medicine
  • Gastroenterology
  • Neuroscience

Background:

  • Chronic constipation impacts approximately 20% of the global population, with limited therapeutic options.
  • Current treatments for chronic constipation often lack efficacy and can have side effects.

Purpose of the Study:

  • To explore the potential of colonic electric stimulation (CES) as a novel therapeutic strategy for chronic constipation.
  • To review the neurophysiology, pathophysiology, and technical considerations of CES.

Main Methods:

  • Review of neurophysiological mechanisms of colonic peristalsis.
  • Analysis of chronic constipation pathophysiology.
  • Examination of technical aspects of CES, including stimulation parameters and electrode placement.
  • Comprehensive review of animal models for CES research.

Main Results:

  • CES, utilizing neural implants, presents a viable bioelectronic medicine approach.
  • Understanding neurophysiology and pathophysiology is crucial for effective CES target selection.
  • Animal models provide mechanistic insights but have limitations in translational relevance.

Conclusions:

  • CES holds significant promise for treating chronic constipation.
  • Further research and development are needed to overcome challenges in CES implementation.
  • Advancements in bioelectronic medicine are key to realizing CES's therapeutic potential.