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Updated: Jun 29, 2025

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Ammoniagenic Action of Valproate without Signs of Hepatic Dysfunction in Rats: Possible Causes and Supporting

Gubidat Alilova1, Lyudmila Tikhonova1, Carmina Montoliu2,3

  • 1Laboratory of Cell Engineering, Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, 142290 Pushchino, Russia.

Biomolecules
|March 28, 2024
PubMed
Summary

Valproic acid (VPA) can increase ammonia in specific rat brain regions, even without liver issues. This study reveals VPA

Keywords:
ammoniagenesis in the rat brainencephalopathy without liver failurevalproate

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