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[In vitro antibacterial activity of fosfomycin]
Giornale Di Batteriologia, Virologia Ed Immunologia
|January 1, 1979
Summary
Phosphonomycin shows good in vitro antibacterial activity, particularly against Gram-positive bacteria. Combining it with cell-wall synthesis inhibitors enhances its effectiveness, though high resistance was observed in Klebsiella spp.
Area of Science:
- Microbiology
- Pharmacology
Context:
- Investigating the in vitro antibacterial properties of phosphonomycin.
- Assessing phosphonomycin's efficacy against 93 freshly isolated bacterial strains.
- Evaluating the synergistic effects of phosphonomycin with other antibiotics.
Purpose:
- To determine the antibacterial spectrum of phosphonomycin.
- To explore combination therapies for enhanced antibacterial activity.
- To quantify the frequency of phosphonomycin resistance in bacterial isolates.
Summary:
- Phosphonomycin exhibits significant in vitro activity against Gram-positive bacteria.
- Combination therapy with phosphonomycin and cell-wall synthesis inhibitors markedly increases antibacterial efficacy.
- High frequencies of phosphonomycin-resistant mutants were identified in Klebsiella spp.
Impact:
- Highlights phosphonomycin's potential as a therapeutic agent, especially against Gram-positive infections.
- Suggests combination strategies to overcome resistance and improve treatment outcomes.
- Identifies Klebsiella spp. as a potential concern for phosphonomycin resistance, guiding future clinical use and research.