Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a...

Area of Science:

• Nephrology
• Otolaryngology
• Epidemiology

Background:

• Chronic kidney disease (CKD) is a major global health concern.
• Emerging evidence suggests a potential link between CKD and chronic rhinosinusitis (CRS).
• The direct association between CKD and CRS requires further investigation.

Purpose of the Study:

• To investigate the association between CKD and the incidence of CRS.
• To evaluate the risk of developing CRS in patients with CKD.
• To analyze the association considering the presence of nasal polyps.

Main Methods:

• Retrospective cohort study using Korean National Health Insurance Service data.
• Inclusion of 16,644 CKD patients and 66,576 matched controls.
• Analysis of incidence rates and adjusted hazard ratios for CRS, with subgroup analysis for CRS with nasal polyps.

Main Results:

• The CKD group showed a higher incidence of CRS (18.30 per 10,000 person-years) compared to controls (13.10 per 10,000 person-years).
• CKD was associated with an increased risk of CRS (adjusted hazard ratio = 1.28).
• No statistically significant correlation was found for CRS with nasal polyps in the CKD group.

Conclusions:

• Chronic kidney disease is associated with an elevated risk of developing chronic rhinosinusitis.
• The findings suggest a clinically relevant link between kidney health and sinonasal disease.
• Further research may explore underlying mechanisms connecting CKD and CRS.