Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Stem Cell Culture01:17

Stem Cell Culture

5.2K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.2K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Embryonic Stem Cells00:58

Embryonic Stem Cells

27.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
27.4K
Bone Cells and Tissue01:30

Bone Cells and Tissue

4.6K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
4.6K
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

4.8K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human BMP4 mRNA Encapsulated in Lipid Nanoparticle for Bone and Articular Cartilage Repair in Aged Mice.

Journal of functional biomaterials·2026
Same author

Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Implications.

JBJS reviews·2026
Same author

Protein-Encoding Chemically Modified mRNAs for Musculoskeletal Tissue Regeneration and Repair.

Journal of functional biomaterials·2026
Same author

What's New in Biologics.

The Journal of bone and joint surgery. American volume·2026
Same author

Cornerstone of healthy ageing: preserving skeletal muscle to delay age-related musculoskeletal disease and maintain functional independence.

British journal of sports medicine·2026
Same author

Hip Chondrolabral Dysfunction: The Road From Excision to Repair, Replacement, and Regeneration.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society·2026

Related Experiment Video

Updated: Jun 29, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

987

Stem Cells and Bone Tissue Engineering.

Xueqin Gao1, Joseph J Ruzbarsky1,2, Jonathan E Layne1

  • 1Linda and Mitch Hart Center for Regenerative and Personalized Medicine, Steadman Philippon Research Institute, Vail, CO 81657, USA.

Life (Basel, Switzerland)
|March 28, 2024
PubMed
Summary
This summary is machine-generated.

Developing new strategies for bone tissue engineering is crucial for treating bone defects. This review explores various stem cells and exosomes for bone repair, highlighting their pros and cons for future regenerative therapies.

Keywords:
adipose-derived stem cellsbone marrow mesenchymal stem cellsbone morphogenetic proteinsbone tissue engineeringdental pulp stem cellsexosomeextracellular vesiclesmicroRNAmuscle-derived stem cellsperiodontal ligament stem cellsperiosteum stem cellsperipheral blood stem cellsumbilical cord-derived stem cellsurine-derived stem cells

More Related Videos

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

21.2K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K

Related Experiment Videos

Last Updated: Jun 29, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

987
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

21.2K
Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
10:03

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging

Published on: August 1, 2017

11.7K

Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Orthopedic Surgery

Background:

  • Segmental bone defects pose significant challenges in treatment due to limitations of current methods like autografts and allografts.
  • Existing treatments for bone defects, including host bone autograft and allograft bone, have associated drawbacks such as harvest site comorbidity and poor incorporation.
  • There is a critical need for innovative bone tissue engineering strategies to effectively address bone defects.

Purpose of the Study:

  • To review the progress in utilizing various postnatal stem cells for bone tissue engineering and repair.
  • To summarize advancements in using exosomes or extracellular vesicles with scaffolds for bone regeneration.
  • To discuss the advantages and disadvantages of different stem cell types in bone repair applications.

Main Methods:

  • Comprehensive literature review of stem cell-based bone tissue engineering strategies.
  • Analysis of studies employing mesenchymal stem cells, adipose-derived stem cells, dental pulp stem cells, and other postnatal stem cells.
  • Evaluation of research on exosomes and extracellular vesicles in combination with scaffolds for bone repair.

Main Results:

  • Significant progress has been made over the past three decades in using stem cells for bone tissue engineering.
  • Various stem cell sources, including bone marrow, adipose tissue, dental pulp, and umbilical cord, show promise for bone repair.
  • Exosomes and extracellular vesicles are emerging as viable therapeutic agents for bone regeneration when delivered via scaffolds.

Conclusions:

  • Diverse stem cell types and exosomes offer promising avenues for developing novel bone regenerative therapies.
  • Understanding the specific advantages and disadvantages of each stem cell source is key to optimizing treatment strategies.
  • Translating preclinical findings into clinical applications could revolutionize the treatment of bone defects.