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The frequency distributions of biochemical variables: Gaussian or log-Gaussian?
Abstract:
Serum sodium and total calcium concentrations were measured in 677 apparently healthy Caucasian men aged 30-39 years. The frequency distributions of these variables could be described equally satisfactorily as either Gaussian or log-Gaussian. Since other biochemical variables (for example, serum bilirubin and alkaline phosphatase) have frequency distributions which are much better described as log-Gaussian, the unifying hypothesis is proposed that all biochemical variables have basically log-Gaussian distributions, and that the apparently Gaussian distributions of certain variables (such as sodium and calcium) arise because of the relatively narrow ranges of values encountered in the healthy population.
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