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Sympathetic Nervous Influences Are Negative Prognostic Factors in Stomach Cancer
Mihai Petrescu1, Georgică Târtea2, Ion Udriștoiu1
1Department of Psychiatry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Life (Basel, Switzerland)
|March 28, 2024
Summary
Increased sympathetic nerve fibers and beta 2 adrenergic receptors in stomach tumors are linked to a worse prognosis. Lower levels correlate with better survival rates for gastric carcinoma patients.
Area of Science:
- Oncology
- Neuroscience
- Pathology
Background:
- Gastric carcinoma progression is influenced by the tumor microenvironment.
- The role of the sympathetic nervous system in cancer development is an emerging area of research.
Purpose of the Study:
- To investigate the association between sympathetic neuronal fibers, beta 2 adrenoreceptors, and gastric cancer progression.
- To determine the prognostic value of these markers in patients with stomach cancer.
Main Methods:
- Retrospective analysis of clinical, biological, and histological data from 104 gastric carcinoma patients.
- Immunohistochemical assessment of beta 2 adrenoreceptor expression and sympathetic fiber density within tumor tissues.
Main Results:
- Increased beta 2 adrenoreceptor expression correlated with larger tumor size (>5 cm), deeper invasion (T3-4), lymph node involvement (>2), and advanced TNM stage (III-IV).
- Patients with low beta 2 adrenoreceptor expression (B2A-) showed significantly better 3-year survival (65%) compared to B2A+ patients (43%).
- Higher density of intra-tumoral sympathetic fibers was associated with poorer survival rates (24%) versus lower density (83%).
Conclusions:
- Elevated sympathetic nerve fiber density and beta 2 adrenergic receptor expression indicate a more unfavorable prognosis in gastric cancer.
- These markers may serve as potential prognostic indicators for stomach cancer patients.
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