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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Related Experiment Video

Updated: Jun 29, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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Transcription Factor MYB as Therapeutic Target: Current Developments.

Karl-Heinz Klempnauer1

  • 1Institute for Biochemistry, University of Münster, 48149 Münster, Germany.

International Journal of Molecular Sciences
|March 28, 2024
PubMed
Summary

The MYB protein regulates key cell processes and is implicated in cancer. This review covers MYB

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • The MYB protein is a crucial transcription factor involved in cell proliferation, differentiation, and apoptosis.
  • Dysregulation of MYB contributes to oncogenesis, making it a significant target in cancer therapy.

Purpose of the Study:

  • To review the molecular functions of the MYB protein.
  • To summarize current therapeutic strategies targeting MYB's oncogenic activity.

Main Methods:

  • Literature review of MYB protein functions.
  • Analysis of therapeutic approaches for MYB inhibition in cancer.

Main Results:

  • MYB protein plays a central role in cellular transcriptional networks.
Keywords:
AMLMYBadenoid cystic carcinomagene expressioninhibitorleukemiap300transcription

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  • Various therapeutic strategies are being developed to inhibit MYB's role in cancer.

    • Conclusions:

    • Understanding MYB's molecular functions is key to developing effective cancer treatments.
    • Targeting MYB offers a promising avenue for novel oncological therapies.