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Editorial for the Special Issue "Latest Review Papers in Molecular Oncology 2023"

Carmine Stolfi1

  • 1Department of Systems Medicine, University of Rome "Tor Vergata", 00133 Rome, Italy.

International Journal of Molecular Sciences
|March 28, 2024
PubMed

Insights

Human cancers arise from multistep processes causing abnormal cell growth and loss of apoptosis. This leads to uncontrolled neoplastic cell expansion and metastasis throughout the body.

Area of Science:

  • Oncology and Molecular Biology: Investigating the fundamental mechanisms of human cancer development.

Background:

  • Human cancers result from complex, multistep processes.
  • Key events include abnormal cell growth, differentiation, and apoptosis evasion.
  • These alterations drive uncontrolled neoplastic cell proliferation and spread.

Discussion:

  • The uncontrolled expansion of neoplastic cells is a hallmark of cancer.
  • Loss of apoptotic function contributes significantly to tumor progression.
  • Metastasis involves the spread of cancer cells to surrounding tissues and distant organs.

Key Insights:

  • Cancer is a multistep disease involving genetic and cellular dysregulation.
  • Apoptosis evasion is critical for tumor survival and growth.
  • Understanding these processes is vital for developing effective cancer therapies.

Outlook:

  • Further research into cancer's multistep nature can reveal new therapeutic targets.
  • Investigating apoptosis pathways may offer strategies to combat cancer progression.
  • Elucidating the mechanisms of metastasis is crucial for improving patient outcomes.

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