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Onco-Hypertension: A Continuously Developing Field between Cancer and Hypertension.
Stefan Totolici1,2, Ana-Maria Vrabie1,2, Elisabeta Badila1,2
1Cardio-Thoracic Pathology Department, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
International Journal of Molecular Sciences
|March 28, 2024
Summary
Novel cancer treatments improve survival but increase cardiovascular risks like hypertension (HT). This onco-hypertension field explores the complex link between cancer and HT, including drug effects.
Area of Science:
- Cardiovascular Medicine
- Oncology
- Pharmacology
Background:
- Cancer patient prognosis has improved due to novel chemotherapies.
- Cardiovascular adverse reactions, particularly arterial hypertension (HT), are increasingly common in cancer patients.
- HT is a frequent comorbidity impacting cancer survivor outcomes and may even be a risk factor for cancer development.
Purpose of the Study:
- To explore the complex relationship between cancer and hypertension.
- To investigate the potential oncogenic effects of antihypertensive drugs.
- To introduce the concept of onco-hypertension for better understanding and management.
Main Methods:
- Review of current literature on chemotherapy-induced hypertension.
- Analysis of studies on hypertension as a cancer risk factor.
- Examination of evidence regarding antihypertensive drugs and cancer risk.
Main Results:
- Chemotherapy can cause secondary hypertension, sometimes severe enough to halt treatment.
- Hypertension itself may be linked to cancer development.
- Some antihypertensive drugs, like thiazide diuretics, may increase skin cancer risk.
Conclusions:
- The interplay between cancer and hypertension is complex, involving shared risk factors and mechanisms.
- The emerging field of onco-hypertension aims to balance the risks and benefits of treatments for both conditions.
- Further research is needed to optimize patient care at the intersection of cancer and hypertension.
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