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Overcoming microbial resuscitation using stable ultrafine gold nanosystems
Anindita Thakur1, Pranay Amruth Maroju1, Ramakrishnan Ganesan2
1Department of Biological Sciences, Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Medchal District Hyderabad Telangana - 500078 India jayati@hyderabad.bits-pilani.ac.in.
Nanoscale Advances
|March 28, 2024
Summary
Ultrafine gold nanosystems (UGNs) can prevent bacterial resuscitation, a factor in antimicrobial resistance. However, UGN exposure may cause cross-resistance to antibiotics, highlighting a critical concern for public health.
Area of Science:
- Nanotechnology
- Microbiology
- Antimicrobial Resistance
Background:
- Ultrafine gold nanosystems (UGNs) show antimicrobial potential.
- Bacterial resuscitation is a key factor in antimicrobial resistance.
- Limited research exists on UGNs' impact on bacterial resuscitation.
Purpose of the Study:
- To investigate the effect of UGNs on bacterial resuscitation.
- To explore how UGN stability and surface accessibility influence this effect.
- To assess potential cross-resistance to conventional antibiotics.
Main Methods:
- Synthesized two categories of UGNs with varying stability and surface accessibility using glutathione capping.
- Exposed bacterial cultures to these UGNs.
- Assessed bacterial resuscitation rates and developed resistance.
- Tested for cross-resistance against conventional antibiotics.
Main Results:
- UGNs demonstrated a capacity to mitigate bacterial resuscitation.
- Modulated UGN stability and surface accessibility influenced the anti-resuscitation effect.
- Observed development of moderate resistance to UGNs.
- Documented significant cross-resistance to conventional antibiotics following UGN exposure.
Conclusions:
- UGNs offer a novel strategy to combat bacterial resuscitation.
- Careful modulation of UGN properties is crucial for efficacy.
- The potential for UGN-induced cross-resistance to antibiotics necessitates further investigation and cautious application.
