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Updated: Jun 29, 2025
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An Alternative Approach to Study Primary Events in Neurodegeneration Using Ex Vivo Rat Brain Slices
Published on: April 11, 2018
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Neurophysiological trajectories in Alzheimer's disease progression.
Kiwamu Kudo1,2, Kamalini G Ranasinghe3, Hirofumi Morise1,2
1Biomagnetic Imaging Laboratory, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, United States.
Elife
|March 28, 2024
Summary
Neural synchrony changes, specifically decreased alpha and beta bands, appear early in Alzheimer's disease (AD) progression, preceding neurodegeneration and cognitive decline. These alterations highlight early functional brain deficits in AD.
Area of Science:
- Neuroscience
- Biomedical Engineering
Background:
- Alzheimer's disease (AD) involves amyloid-β and tau protein accumulation, leading to synaptic dysfunction, neurodegeneration, and cognitive decline.
- Altered neural oscillations are a known feature of AD, but their progression and relation to disease severity remain unclear.
Purpose of the Study:
- To investigate the progression of abnormal neural synchrony across different stages of Alzheimer's disease.
- To determine the relationship between neural synchrony trajectories and neurodegeneration and cognitive decline in AD.
Main Methods:
- Utilized event-based sequencing models (EBMs) to analyze resting-state magnetoencephalography (MEG) data.
- Estimated trajectories of long-range and local neural synchrony across AD stages.
Main Results:
- Observed progressive changes in neural synchrony: increases in delta-theta bands and decreases in alpha and beta bands throughout AD stages.
- Decreases in alpha and beta band synchrony were found to precede neurodegeneration and cognitive decline.
- Long-range synchrony changes were more pronounced than local synchrony changes.
Conclusions:
- Frequency-specific abnormalities in neuronal synchrony are early indicators of Alzheimer's disease pathophysiology.
- Altered neural synchrony, particularly long-range connectivity, evolves progressively throughout the course of AD, reflecting functional neuronal deficits.
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