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Adoption of Decentralization: Are Our Perceptions Holding Us Back?
Lindsay Kehoe1, Sara Bristol Calvert1, Zachary Hallinan1
1Clinical Trials Transformation Initiative, Duke Clinical Research Institute, 300 West Morgan Street, Suite 800, Durham, NC, 27701, United States.
Decentralized clinical trials (DCTs) offer improved accessibility and reduced participant burden. This commentary addresses common misconceptions hindering DCT adoption, providing resources to overcome these barriers and advance trial modernization.
Area of Science:
- Clinical trial modernization
- Digital health in research
- Decentralized clinical trials (DCTs)
Background:
- Decentralized approaches in clinical trials present opportunities for enhanced accessibility, diversity, and reduced participant/caregiver burden.
- Despite potential benefits, significant hurdles are perceived to impede the widespread adoption of digital and decentralized clinical trials.
Purpose of the Study:
- To critically examine commonly perceived impediments to adopting digital and decentralized clinical trials.
- To offer insights and resources to overcome these perceived barriers and foster confidence in DCT implementation.
Main Methods:
- The commentary leverages insights from the Clinical Trial Transformation Initiative's Digital Health Trial hub.
- It includes interactions with industry members and regulatory bodies, alongside observations on adoption trends.
Main Results:
- Identifies and addresses three prevalent perceptions that function as barriers to digital and decentralized clinical trial adoption.
- Highlights existing resources and strategies to mitigate these perceived challenges.
Conclusions:
- Addressing common misconceptions about decentralized clinical trials is crucial for their successful integration.
- By overcoming these perceived hurdles, sponsors and designers can confidently utilize advanced tools to modernize clinical trials and increase the use of decentralized approaches.
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