Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Next-generation Sequencing03:00

Next-generation Sequencing

88.7K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
88.7K
Sanger Sequencing01:57

Sanger Sequencing

754.2K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
754.2K
DNA as a Genetic Template02:05

DNA as a Genetic Template

21.9K
Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
21.9K
RNA-seq03:21

RNA-seq

9.9K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
9.9K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

11.2K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
11.2K
The DNA Helix01:16

The DNA Helix

139.7K
Overview
139.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intensity fluctuations - driving force of nonlinearity in optical fibers.

Optics express·2025
Same author

SC List-Flip Decoding of Polar Codes by Shifted Pruning: A General Approach.

Entropy (Basel, Switzerland)·2022
Same author

All-optical generation of DFT-S-OFDM superchannels using periodic sinc pulses.

Optics express·2014
Same author

Sensitivity improvement and carrier power reduction in direct-detection optical OFDM systems by subcarrier pairing.

Optics express·2012

Related Experiment Video

Updated: Jun 29, 2025

Sequencing of mRNA from Whole Blood using Nanopore Sequencing
11:26

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

13.7K

Concatenated Nanopore DNA Codes.

Adrian Vidal, V B Wijekoon, Emanuele Viterbo

    IEEE Transactions on Nanobioscience
    |March 28, 2024
    PubMed
    Summary

    Researchers developed a new DNA code construction method for nanopore sequencing data storage. This approach enhances data robustness against sequencing errors by concatenating DNA k-mers, improving storage efficiency and decoding complexity.

    Area of Science:

    • Bioinformatics
    • Molecular Engineering
    • Data Storage

    Background:

    • Nanopore sequencing generates noisy DNA signals.
    • DNA data storage requires robust codes against sequencing errors.
    • Current code design methods are limited by graph complexity.

    Purpose of the Study:

    • To develop a robust DNA code construction for nanopore sequencing.
    • To improve storage efficiency and decoding in DNA data storage.
    • To mitigate noise and channel memory effects in nanopore sequencing.

    Main Methods:

    • Concatenating codewords from a base DNA code.
    • Incorporating a circumfix into the base code to reduce channel memory.
    • Analyzing decoding complexity and error rates through simulations.

    More Related Videos

    Ultra-long Read Sequencing for Whole Genomic DNA Analysis
    10:34

    Ultra-long Read Sequencing for Whole Genomic DNA Analysis

    Published on: March 15, 2019

    22.8K
    Nanopore DNA Sequencing for Metagenomic Soil Analysis
    07:33

    Nanopore DNA Sequencing for Metagenomic Soil Analysis

    Published on: December 14, 2017

    30.5K

    Related Experiment Videos

    Last Updated: Jun 29, 2025

    Sequencing of mRNA from Whole Blood using Nanopore Sequencing
    11:26

    Sequencing of mRNA from Whole Blood using Nanopore Sequencing

    Published on: June 3, 2019

    13.7K
    Ultra-long Read Sequencing for Whole Genomic DNA Analysis
    10:34

    Ultra-long Read Sequencing for Whole Genomic DNA Analysis

    Published on: March 15, 2019

    22.8K
    Nanopore DNA Sequencing for Metagenomic Soil Analysis
    07:33

    Nanopore DNA Sequencing for Metagenomic Soil Analysis

    Published on: December 14, 2017

    30.5K

    Main Results:

    • Constructed large DNA codes by concatenating k-mers.
    • Demonstrated stable base code error rates as concatenated k-mers increase.
    • Showed decoding complexity scales with the number of concatenated k-mers.

    Conclusions:

    • Concatenation offers a scalable method for constructing robust DNA codes.
    • The circumfix aids in reducing nanopore channel memory effects.
    • This method enhances the practicality of DNA-based data storage.