Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antigens Involved in Adaptive Immunity

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...

MALDI-TOF Mass Spectrometry

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Molecular glue degraders: Rational design, specificity engineering, and advanced delivery.

Acta pharmaceutica Sinica. B·2026

Same author

Co-delivery of vitamin D and probiotics and their synergistic improvement of intestinal functions in simulated microgravity rats via zein/sodium caseinate-based microcapsules.

International journal of biological macromolecules·2026

Same author

Alzheimer's disease proteome-wide association study implicates adaptive immunity and identifies risk genes LILRB1 and SIRPA.

Science translational medicine·2026

Same author

Nonlinear Modeling Reveals Novel Associations Between Genetically Predicted Protein Levels and Pancreatic Cancer Risk.

Molecular carcinogenesis·2026

Same author

Multimechanistic actions of functional factors in enhancing physical strength and endurance: a scoping review of nutritional basis and natural extracts.

Frontiers in sports and active living·2026

Same author

Low-Shear Circulation and Layered Regeneration: Coupled Analysis of RCCS-CFD for In Vitro Construction of Active Osteochondral Tissues.

Biotechnology journal·2026

Search research articles

Related Experiment Video

Updated: Jun 29, 2025

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Neoantigen identification: Technological advances and challenges.

Ting Pu¹, Allyson Peddle¹, Jingjing Zhu²

¹Digestive Oncology Unit, KULeuven, Leuven, Belgium.

Methods in Cell Biology

|March 28, 2024

Summary

Neoantigens, unique tumor targets, are crucial for cancer immunotherapies like vaccines. Improved prediction tools are needed, but validated data for immunogenic neoantigens remains a challenge.

Keywords:

Computational tool HLA Immunotherapy Neoantigen Neoantigen prediction Somatic mutation TCR

More Related Videos

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Related Experiment Videos

Last Updated: Jun 29, 2025

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Enrich and Expand Rare Antigen-specific T Cells with Magnetic Nanoparticles

Published on: November 17, 2018

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Generation of Two-color Antigen Microarrays for the Simultaneous Detection of IgG and IgM Autoantibodies

Published on: September 15, 2016

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes

Published on: March 25, 2014

Area of Science:

Oncology
Immunology
Bioinformatics

Background:

Neoantigens are tumor-specific targets arising from genetic and non-genomic alterations.
They are critical for developing personalized cancer vaccines and adoptive cell therapies.
Advancements in technology facilitate the identification of immunogenic neoantigens.

Approach:

Neoantigen prediction requires high-quality samples and sequencing data for mutation calling.
Computational pipelines integrate tools for predicting expression, processing, binding, and recognition.
The review summarizes current knowledge and limitations in neoantigen prediction and validation.

Key Points:

Neoantigens encompass genomic mutations, post-transcriptomic variants, and viral oncoproteins.
Accurate prediction relies on robust computational pipelines and validated datasets.
Understanding neoantigen origin and biological roles enhances their therapeutic potential.

Conclusions:

Neoantigen prediction and validation are essential for advancing cancer immunotherapy.
Further development of computational tools is hampered by the lack of validated immunogenic neoantigen datasets.
Harnessing neoantigens offers significant promise in the fight against cancer.