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Nontraditional Treatment of Hepatic Encephalopathy
Jasleen Singh1, Brittney Ibrahim2, Steven-Huy Han3
1Department of Medicine, University of California at Los Angeles; Los Angeles, CA, USA.
Clinics in Liver Disease
|March 28, 2024
Summary
Hepatic encephalopathy (HE) treatments focus on ammonia reduction. Nontraditional therapies and procedures offer alternatives for patients unresponsive to standard care, but more research is needed.
Area of Science:
- Hepatology
- Gastroenterology
- Neuroscience
Background:
- Hepatic encephalopathy (HE) pathophysiology is complex, with hyperammonemia as a key factor.
- Standard HE treatments target ammonia, including lactulose and rifaximin.
- Nontraditional therapies and procedures address other HE pathogenesis factors.
Purpose of the Study:
- To review traditional and nontraditional treatments for hepatic encephalopathy.
- To discuss procedural therapies for refractory HE.
- To highlight the need for further research on alternative HE treatments.
Main Methods:
- Literature review of HE pathophysiology and treatment options.
- Analysis of traditional, nontraditional, and procedural therapies.
- Evaluation of evidence supporting alternative HE management strategies.
Main Results:
- Standard therapies like lactulose and rifaximin are effective for many HE patients.
- Nontraditional treatments and procedures offer alternatives for treatment-resistant HE.
- Liver transplant remains the definitive cure for severe HE.
Conclusions:
- Alternative treatments for HE show promise for patients failing standard care.
- Procedural therapies like albumin dialysis and shunt closure are viable options.
- High-quality studies are required to establish routine recommendations for novel HE therapies.
Keywords:
Albumin dialysisAmmoniaBranched chain amino acidsFecal microbiota transplantLiver transplantationNontraditional treatmentsProbioticsgut microbiomeMore Related Videos
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