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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
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Identifying patients with acute aortic dissection using an electrocardiogram with convolutional neural network.

Takuto Arita1, Shinya Suzuki1, Jun Motogi2

  • 1Department of Cardiovascular Medicine, The Cardiovascular Institute, Tokyo, Japan.

International Journal of Cardiology. Heart & Vasculature
|March 29, 2024
PubMed
Summary

Artificial intelligence (AI) with electrocardiography (ECG) shows promise for screening aortic dissection (AD). A convolutional neural network (CNN) model achieved a 35% positive predictive rate (PPR) in high-risk patients, improving AD detection.

Keywords:
Aortic dissectionArtificial intelligenceConvolutional neural networkElectrocardiography

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Area of Science:

  • Cardiology
  • Artificial Intelligence
  • Medical Diagnostics

Background:

  • Electrocardiography (ECG) combined with artificial intelligence (AI) offers potential for initial screening of aortic dissection (AD).
  • Achieving a high positive predictive rate (PPR) for AI-based AD detection remains a significant challenge.

Purpose of the Study:

  • To evaluate the performance of a convolutional neural network (CNN) model for detecting aortic dissection (AD) using digital 12-lead ECG data.
  • To assess the impact of different ECG lead configurations and patient risk factors on the CNN model's diagnostic accuracy and PPR.

Main Methods:

  • A retrospective analysis of a prospective cohort study (Shinken Database, 2010-2017, N=19,170) utilizing digital 12-lead ECGs.
  • A CNN model was trained and validated using five-fold cross-validation on eight-lead, single-lead, and double-lead ECG configurations for AD detection.
  • Performance metrics including area under the curve (AUC) and positive predictive rate (PPR) were assessed across the entire cohort and in subgroups with elevated D-dimer and hypertension history.

Main Results:

  • The CNN model achieved an AUC of 0.936 with eight-lead ECGs for AD detection.
  • In the overall cohort, the model had a 7% PPR and 86% sensitivity for AD.
  • Applying the CNN to patients with D-dimer levels ≥1 μg/dL and hypertension history increased PPR to 35% (86% sensitivity).
  • A single V1 lead ECG configuration demonstrated high diagnostic performance (AUC: 0.933) and improved PPR to 38% in the same high-risk subgroup.

Conclusions:

  • The developed CNN model demonstrates effective AD detection using ECG data, achieving over 30% PPR in high-risk patients while maintaining sensitivity.
  • A single V1 lead ECG offers a simplified yet highly effective approach for AI-driven AD screening within the CNN framework.
  • These findings suggest that AI-powered ECG analysis can significantly enhance the initial screening of aortic dissection, particularly in at-risk populations.