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Persistent clonotypes associated with group A streptococcal polysaccharide antibody response in man
International Archives of Allergy and Applied Immunology
|January 1, 1979
Summary
Elevated antibodies against streptococcal group A are found in acute rheumatic fever patients. This stable antibody pattern persists even with reinfection, suggesting long-term immunity is linked to consistent antibody expression.
Area of Science:
- Immunology
- Rheumatology
- Infectious Diseases
Background:
- Acute rheumatic fever (ARF) is an inflammatory condition following streptococcal infection.
- Antibodies against streptococcal group A polysaccharide are markers in ARF patients.
Purpose of the Study:
- To investigate the persistence and pattern of anti-group A polysaccharide antibodies in ARF patients.
- To determine the relationship between antibody clonotype expression and naturally acquired immunity in ARF.
Main Methods:
- Sera from ARF patients were analyzed using analytical isoelectric focusing.
- Samples were collected during the acute phase and sequentially for up to 2 years.
- Antibody clonotype patterns were examined in relation to disease recurrence and reinfection.
Main Results:
- A stable clonotype pattern of anti-group A polysaccharide antibodies was identified in ARF patients.
- This specific antibody pattern remained consistent over a 2-year follow-up period.
- The same clonotype pattern was observed in patients experiencing reinfection and ARF recurrence.
Conclusions:
- Naturally acquired immunity in ARF is associated with the persistence of a specific antibody clonotype expression.
- The stable antibody pattern suggests a long-lasting immunological memory against streptococcal group A.
- Further research into this persistent antibody response may offer insights into ARF prevention and management.