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Updated: Jun 29, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
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The multifaceted therapeutic value of targeting steroid receptor coactivator-1 in tumorigenesis

Qiang Chen1,2, Peng Guo3,4, Yilin Hong4

  • 1Zhejiang Key Laboratory of Pathophysiology, Department of Biochemistry and Molecular Biology, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, China. chenqiang1@nbu.edu.cn.

Cell & Bioscience
|March 30, 2024
PubMed

Insights

Steroid receptor coactivator-1 (SRC-1) drives cancer progression by altering gene expression and chromatin accessibility. While inhibiting SRC-1 shows anti-tumor potential, its clinical application for cancer therapy remains limited.

Area of Science:

  • Molecular Biology
  • Oncology
  • Epigenetics

Background:

  • Steroid receptor coactivator-1 (SRC-1, also known as NCOA1) is a key transcriptional coactivator.
  • SRC-1 plays a significant role in tumorigenesis across various cancers, including breast, prostate, and gastrointestinal cancers.
  • Its function extends beyond steroid hormone-producing tissues, indicating a broader oncogenic role.

Purpose of the Study:

  • To review the oncogenic role of SRC-1 in cancer progression.
  • To identify SRC-1's major collaborators and regulatory genes.
  • To map the mechanisms by which SRC-1 promotes primary tumor progression.

Main Methods:

  • Literature review of evidence on SRC-1's oncogenic functions.
  • Analysis of SRC-1's interactions with transcription factors and regulatory genes.
  • Mapping of molecular mechanisms involved in SRC-1-mediated gene transcription and chromatin remodeling.

Main Results:

  • SRC-1 promotes gene transcription by enhancing chromatin accessibility and forming transcriptional complexes.
  • SRC-1 facilitates the progression of multiple cancer types.
  • Emerging evidence suggests novel coactivation patterns independent of androgen receptor (AR) or estrogen receptor (ER).

Conclusions:

  • SRC-1 is a critical facilitator of tumor progression through diverse molecular mechanisms.
  • Pharmacological inhibition of SRC-1 presents a potential therapeutic strategy, but clinical applications are currently limited.
  • Further research is needed to fully elucidate SRC-1's multiorgan oncogenic role and develop effective therapeutic interventions.
Keywords:
NCOA1SRC-1Steroid hormoneTumour progression

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