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Updated: Jun 29, 2025

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FAIR Header Reference genome: a TRUSTworthy standard
Adam Wright1, Mark D Wilkinson2, Christopher Mungall3
1Adaptive Oncology Program, Ontario Institute for Cancer Research, 661 University Avenue Suite 500, Toronto, ON M5G 0A3, Canada.
FAIR bioHeaders Reference genome (FHR) is a new metadata standard that improves genomic data sharing. It ensures data findability, accessibility, and interoperability, reducing data provenance loss.
Area of Science:
- Genomics
- Bioinformatics
- Data Science
Background:
- Lack of interoperable data standards hinders cross-platform genomic analysis.
- Reference genome data-sharing platforms face risks of data provenance loss.
Purpose of the Study:
- Introduce the FAIR bioHeaders Reference genome (FHR) metadata standard.
- Address challenges in genomic data sharing and provenance.
Main Methods:
- Developed FHR based on FAIR principles (Findability, Accessibility, Interoperability, Reuse) and other key principles.
- Defined minimum data fields and extensibility for a decentralized ecosystem.
Main Results:
- FHR offers a comprehensive metadata standard for reference genomes.
- The standard is designed for low implementation effort, maintaining data provenance.
Conclusions:
- FHR facilitates enhanced data sharing and analysis across platforms.
- The standard supports a decentralized genomic data ecosystem with robust provenance tracking.
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