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FAIR Header Reference genome: a TRUSTworthy standard.

Adam Wright1, Mark D Wilkinson2, Christopher Mungall3

  • 1Adaptive Oncology Program, Ontario Institute for Cancer Research, 661 University Avenue Suite 500, Toronto, ON M5G 0A3, Canada.

Briefings in Bioinformatics
|March 30, 2024
PubMed
Summary
This summary is machine-generated.

FAIR bioHeaders Reference genome (FHR) is a new metadata standard that improves genomic data sharing. It ensures data findability, accessibility, and interoperability, reducing data provenance loss.

Keywords:
FASTAReference Genomedata managementnetwork effectprovenance

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Area of Science:

  • Genomics
  • Bioinformatics
  • Data Science

Background:

  • Lack of interoperable data standards hinders cross-platform genomic analysis.
  • Reference genome data-sharing platforms face risks of data provenance loss.

Purpose of the Study:

  • Introduce the FAIR bioHeaders Reference genome (FHR) metadata standard.
  • Address challenges in genomic data sharing and provenance.

Main Methods:

  • Developed FHR based on FAIR principles (Findability, Accessibility, Interoperability, Reuse) and other key principles.
  • Defined minimum data fields and extensibility for a decentralized ecosystem.

Main Results:

  • FHR offers a comprehensive metadata standard for reference genomes.
  • The standard is designed for low implementation effort, maintaining data provenance.

Conclusions:

  • FHR facilitates enhanced data sharing and analysis across platforms.
  • The standard supports a decentralized genomic data ecosystem with robust provenance tracking.