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Updated: Jun 29, 2025

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products
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[The Applications of qNMR in Drug Quality Control]

Eri Ena1, Yumi Asai1, Takashi Hasebe1

  • 1Analytical Research, Pharmaceutical Science & Technology Unit, Pharmaceutical Profiling & Development Function DHBL, Eisai Co., Ltd.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|March 31, 2024
PubMed
Summary

Quantitative NMR (qNMR) is a powerful analytical technique for drug development, offering absolute quantitation without reference standards. This method requires minimal sample and is versatile, even determining residual solvents as an alternative to GC.

Keywords:
absolute quantitationdrug quality controlquantitative NMR (qNMR)residual solvent

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