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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Orthotopic Mouse Model of Colorectal Cancer

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Published on: December 4, 2007

Peritoneal carcinomatosis in mouse models.

Leire Arrizabalaga¹, Claudia Augusta Di Trani¹, Aline Risson¹

¹Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.

Methods in Cell Biology

|March 31, 2024

Summary

Researchers developed a new method to create syngeneic mouse models for peritoneal carcinomatosis (PCa). This breakthrough aids in developing novel therapies for this aggressive cancer, offering hope for improved patient outcomes.

Keywords:

Animal models Ascites Omentum Peritoneal carcinomatosis Tumor models

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Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

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Published on: December 9, 2016

A Preclinical Murine Model of Hepatic Metastases

A Preclinical Murine Model of Hepatic Metastases

Published on: September 27, 2014

Area of Science:

Oncology
Translational Medicine
Animal Models

Background:

Peritoneal carcinomatosis (PCa) is an advanced metastatic disease with limited therapeutic options and a poor prognosis.
Effective treatments for PCa are currently available only for a small subset of patients with low tumor burden.
The development of reliable animal models is crucial for discovering new and effective therapies for PCa.

Purpose of the Study:

To describe a method for generating syngeneic mouse models of peritoneal carcinomatosis (PCa).
To establish a reproducible and monitorable preclinical platform for evaluating novel PCa therapies.

Main Methods:

Generation of syngeneic PCa mouse models via intraperitoneal (i.p.) administration of tumor cells.
Monitoring of cancer progression through body weight changes, ascites development, and overall survival.
Utilizing luciferase-expressing tumor cells for in vivo bioluminescence quantification to assess tumor growth.

Main Results:

Successful establishment of reproducible syngeneic PCa mouse models from ovarian and colorectal origins.
Demonstrated feasibility of monitoring disease progression and tumor growth using established parameters.
Validated the utility of the model for preclinical evaluation of therapeutic strategies.

Conclusions:

The described method provides a reliable and easy-to-monitor syngeneic mouse model for PCa.
This model is a critical first step towards developing innovative therapies for peritoneal carcinomatosis.
Advancements in preclinical models are essential for improving treatment outcomes in advanced cancers.