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Safety and Effectiveness of Probiotics in Preterm Infants with Necrotizing Enterocolitis

Laura N Calvo1, Rachel G Greenberg1,2, Keyaria D Gray1

  • 1Department of Pediatrics, Duke University School of Medicine, Durham, NC.

Neoreviews
|March 31, 2024
PubMed

Insights

Necrotizing enterocolitis (NEC) in preterm infants is linked to gut dysbiosis. This review examines probiotics as a potential intervention to improve gut health and reduce NEC rates in vulnerable newborns.

Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Gastroenterology

Background:

  • Necrotizing enterocolitis (NEC) is a significant cause of illness and death in premature infants.
  • The exact causes of NEC are not fully understood, but gut dysbiosis (microbial imbalance) is a suspected major factor.
  • Altered gut microbiota in preterm infants may predispose them to NEC development.

Conclusions:

  • Gut dysbiosis is a critical factor in necrotizing enterocolitis pathogenesis.
  • Probiotics represent a promising therapeutic strategy for NEC prevention in preterm infants.
  • Continued investigation into probiotic efficacy and safety is warranted for clinical application.

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