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In vitro activity of cefoxitin, imipenem, meropenem, and ceftaroline in combination with vaborbactam against
Liang Chen1,2, Elena Shashkina1, Natalia Kurepina1
1Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Abstract:
Mycobacterium abscessus (MAB) infections pose a growing public health threat. Here, we assessed the in vitro activity of the boronic acid-based β-lactamase inhibitor, vaborbactam, with different β-lactams against 100 clinical MAB isolates. Enhanced activity was observed with meropenem and ceftaroline with vaborbactam (1- and >4-fold MIC50/90 reduction). CRISPRi-mediated blaMAB gene knockdown showed a fourfold MIC reduction to ceftaroline but not the other β-lactams. Our findings demonstrate vaborbactam's potential in combination therapy against MAB infections.
