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Systemic and Neurosarcoidosis With Rare Involvement of the Extremities' Peripheral Nerves
Fathima Fijula Palot Manzil1, Joshua Eichhorn1, Harleen Kaur2
1From the University of Arkansas for Medical Sciences, Little Rock, AR.
Clinical Nuclear Medicine
|April 1, 2024
Summary
This study reports a rare case of sarcoidosis affecting peripheral nerves and skin. 18F-FDG PET/CT imaging revealed uncommon sarcoidosis manifestations, aiding diagnosis.
Area of Science:
- Neurology
- Nuclear Medicine
- Oncology
Background:
- Sarcoidosis is a multisystem inflammatory disease of unknown etiology.
- While central nervous system involvement is documented, peripheral nervous system involvement is rare.
Observation:
- A patient presented with rare sarcoidosis manifestations including peripheral lower limb nerve involvement and subcutaneous nodules.
- 18F-FDG PET/CT imaging identified these uncommon sites of disease.
- Histological examination confirmed sarcoidosis of spinal nerves and dura.
Findings:
- 18F-FDG PET/CT effectively visualized rare peripheral nerve and subcutaneous sarcoidosis.
- Systemic sarcoidosis was evidenced by metabolically active cervical and mediastinal lymphadenopathy.
- This case represents a unique presentation of peripheral nervous system sarcoidosis.
Implications:
- Highlights the utility of 18F-FDG PET/CT in diagnosing uncommon sarcoidosis presentations.
- Suggests considering peripheral nerve involvement in sarcoidosis evaluations.
- Contributes to the understanding of sarcoidosis' diverse clinical spectrum.
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