Enhanced fluoride uptake from mouthrinses.

Area of Science:

• Biomaterials Science
• Dental Research
• Fluoride Chemistry

Background:

• Pre-treatment forming dicalcium phosphate dihydrate (DCPD) increases enamel reactivity to fluoride.
• Previous laboratory and animal studies suggest enhanced fluoride uptake after DCPD formation.

Purpose of the Study:

• To investigate the impact of DCPD-forming rinses on human enamel fluoride uptake within a conventional fluoride rinsing regimen.
• To assess if incorporating DCPD intermediates enhances the efficacy of daily 0.2% sodium fluoride (NaF) rinses.

Main Methods:

• Human enamel samples were subjected to daily 0.2% NaF rinses for 20 days.
• A second group received the same NaF treatment plus intermittent DCPD-forming rinses.
• Labile fluoride was removed using 1 M KOH post-treatment, followed by enamel biopsy analysis.

Main Results:

• Fluoride uptake from 0.2% NaF rinses alone was not statistically significant.
• Fluoride uptake was statistically significant when DCPD-forming rinses were combined with NaF rinses.
• The incorporation of DCPD intermediates demonstrated a measurable increase in fluoride retention.

Conclusions:

• DCPD-forming rinses can significantly enhance fluoride uptake in human enamel.
• This method shows potential for improving the clinical efficacy of fluoride rinse programs.
• The findings suggest a promising strategy for caries prevention through optimized fluoride delivery.