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Single-Cell Atlas Uncovers Layer 4 Heterogeneity and Functional Gradients in Rhesus Macaque Visual Cortex
Dorothee M Günther1,2,3, Mykhailo Y Batiuk4,5, Viktor Petukhov4
1Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society, 60528 Frankfurt, Germany.
Biorxiv : the Preprint Server for Biology
|April 1, 2024
Summary
Single-cell RNA sequencing reveals distinct neuron subtypes in the rhesus macaque visual cortex. Cell density gradients across visual areas V1-TEO suggest organization reflecting the visual processing hierarchy.
Area of Science:
- Neuroscience
- Genomics
- Primate Research
Background:
- The rhesus macaque is a crucial animal model for understanding brain function.
- Previous studies have broadly surveyed the macaque brain's cellular landscape.
- Investigating neighboring visual cortex areas offers insights into functional organization.
Conclusions:
- Neighboring visual areas exhibit distinct areal specializations.
- These specializations correlate with hierarchical levels within the visual cortex.
- Findings provide a high-resolution map of cell types in the macaque visual cortex.
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