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External Disruption of Ocular Development in Utero
Hyun Sue Kim1,2, Soshian Sarrafpour2, Christopher C Teng2
1Virginia Tech Carilion School of Medicine, Roanoke, VA, USA.
The Yale Journal of Biology and Medicine
|April 1, 2024
Summary
External factors during pregnancy significantly impact human ocular development. More research is crucial to understand how these elements affect fetal eye formation and long-term visual health.
Area of Science:
- Developmental Biology
- Ophthalmology
- Teratology
Background:
- Human ocular embryology involves complex cellular and genetic signaling pathways.
- Pregnancy is susceptible to external factors influencing fetal development, including environmental, metabolic, and infectious agents.
Purpose of the Study:
- To review external factors impacting human ocular development during pregnancy.
- To highlight the multifactorial nature and clinical significance of these influences on fetal eye formation.
Main Methods:
- Systematic literature review of English-language articles.
- Databases searched: PubMed, Web of Science, Google Scholar.
- Keywords: ocular development in pregnancy, ocular embryology, maternal nutrition, ophthalmic change, visual system development.
Main Results:
- Animal models demonstrate disruptions in ocular embryology due to external factors.
- Limited human studies provide post-birth assessments of these disruptions.
- Precise mechanisms of *in utero* ocular development disruption remain largely unknown.
Conclusions:
- Understanding the pathophysiology of external factor-induced ocular developmental disruption requires further investigation.
- Additional research is essential to elucidate the dynamic relationship between gestational factors and neonatal ocular development, especially in resource-limited settings.
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