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Author Spotlight: Fu's Subcutaneous Needling for Knee Osteoarthritis Pain
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Skeletal interoception in osteoarthritis.

Dinglong Yang1, Jiawen Xu2, Ke Xu1

  • 1Department of Joint Surgery, Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710054, China.

Bone Research
|April 1, 2024
PubMed
Summary
This summary is machine-generated.

Skeletal interoception, the body's sense of bone status, plays a key role in osteoarthritis (OA) by influencing bone remodeling and inflammation. Targeting this mechanism may offer new OA treatment strategies.

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Area of Science:

  • Physiology
  • Pathology
  • Biomedical Engineering

Background:

  • Interoception regulates physiological conditions and metabolic homeostasis.
  • Skeletal interoception specifically impacts bone metabolic homeostasis.
  • Osteoarthritis (OA) involves cartilage, subchondral bone, and synovial changes.

Purpose of the Study:

  • To provide an overview of interoception and skeletal interoception.
  • To examine the subchondral bone microenvironment and aberrant remodeling in OA.
  • To discuss the role of skeletal interoception in OA pathogenesis and potential therapeutic targets.

Main Methods:

  • Literature review of interoception and osteoarthritis.
  • Analysis of skeletal interoception's role in subchondral bone remodeling.
  • Exploration of skeletal interoception's link to synovial inflammation in OA.

Main Results:

  • Aberrant mechanical loads mediated by skeletal interoception contribute to pathological subchondral bone remodeling and sclerosis in OA.
  • Skeletal interoception is implicated as a potential mechanism for chronic synovial inflammation in OA.
  • Subchondral bone remodeling is a key adaptation to dynamic joint loads in OA.

Conclusions:

  • Skeletal interoception is a critical factor in the aberrant subchondral bone remodeling and synovial inflammation observed in osteoarthritis.
  • Understanding skeletal interoception offers novel therapeutic avenues for osteoarthritis.
  • Further research is needed to explore challenges and prospects of targeting skeletal interoception for OA treatment.