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Antibiotic Development: Lessons from the Past and Future Opportunities.

Michael S Kinch1, Zachary Kraft2, Tyler Schwartz2

  • 1Center for Research Innovation in Biotechnology, Long Island University, Brookville, NY, 11548, USA. michael.kinch@liu.edu.

Pharmaceutical Research
|April 1, 2024
PubMed
Summary
This summary is machine-generated.

Antimicrobial resistance is a growing threat, yet private sector investment in new antibacterial drugs has remained stagnant. Few companies are developing these vital medical countermeasures, despite the urgent need.

Keywords:
antibioticsantimicrobial resistancebacterial infectionsclinical trials

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Area of Science:

  • Infectious Diseases
  • Drug Development
  • Antimicrobial Resistance

Background:

  • Antimicrobial resistance (AMR) poses a significant global health challenge.
  • The development of new medical countermeasures against bacterial infections is crucial.

Purpose of the Study:

  • To assess the progress and trends in the development of antibacterial drugs from 2000 to 2021.
  • To compare private sector activity in antibacterial drug development with other areas, such as oncology.

Main Methods:

  • Analysis of clinical trial data from 2000 to 2021.
  • Evaluation of the number of investigative drugs, their development stages, and the number of involved organizations.

Main Results:

  • Private sector interest in oncology surged, while activity in antibacterial development remained stagnant.
  • A declining number of organizations are actively involved in developing new antibacterial products.
  • Many companies that previously developed antibacterial agents have exited the field.

Conclusions:

  • The development of medical countermeasures against bacterial infections is not keeping pace with the growing threat of antimicrobial resistance.
  • There is a concerning decline in organizational involvement and product development pipelines for new antibacterial drugs.