Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Biopharmaceutical Factors Influencing Drug Product Design: Overview

Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...

Drug Control Governance: Regulatory Bodies and Their Impact

Drug Control Governance: Regulatory Bodies and Their Impact

Drug control governance involves the oversight and regulation of pharmaceuticals to ensure their safety and efficacy while preventing illegal drug use and trafficking. Regulatory bodies, including the US Food and Drug Administration (FDA) and the European Union's European Medicines Agency (EMA), play a central role in this process. These agencies evaluate the safety and efficacy of drugs before they can be marketed. They fund clinical trials and assess the benefits and risks associated with...

Biopharmaceutics and Pharmacokinetics: Overview

Biopharmaceutics and Pharmacokinetics: Overview

Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...

Drug Nomenclature

Drug Nomenclature

During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...

Drug Administration and Therapy Phases: Overview

Drug Administration and Therapy Phases: Overview

Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
The pharmaceutical phase focuses on leveraging the physicochemical properties of the drug to design and manufacture an effective product. Variants include orally administered tablets or capsules, topical creams or ointments, and parenteral-delivery solutions or emulsions.
The pharmacokinetic phase...

Drug Products: Biologics, Biosimilars and Interchangeables

Drug Products: Biologics, Biosimilars and Interchangeables

Body:Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

2025 In Review: Trends in Pharmaceutical Innovation.

Drug discovery today·2026

Same author

Ignore at Your Own Risk: American Academic Contributions to the Development of Small Molecule Therapeutics.

Drug discovery today·2025

Same author

Target & Mechanism Selection in Pharmaceutical Innovation: A Source for Concern or Optimism?

Drug discovery today·2025

Same author

2024 in Review: FDA Approval of New Medicines.

Drug discovery today·2025

Same author

Antibiotic Development: Lessons from the Past and Future Opportunities.

Pharmaceutical research·2024

Same author

2023 in review: FDA approvals of new medicines.

Drug discovery today·2024

Search research articles

Related Experiment Video

Updated: Jan 8, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Geopolitical contributions to pharmaceutical innovation.

Michael S Kinch¹, Aayan Alawi¹, Tyler Schwartz²

¹Department of Pharmaceutical Sciences, Stony Brook University, Stony Brook, NY, USA.

Drug Discovery Today

|December 19, 2025

Summary

New experimental drug discovery has surged globally over 25 years. China

Keywords:

China USA clinical trial drug discovery innovation

More Related Videos

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Related Experiment Videos

Last Updated: Jan 8, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

Pharmaceutical Sciences
Drug Discovery and Development
Global Health Initiatives

Background:

The United States private sector has historically led global new drug introductions.
The landscape of pharmaceutical innovation is dynamic and evolving.
Understanding the origins of new experimental drugs is crucial for future R&D strategies.

Purpose of the Study:

To analyze the geographical sources of new experimental drugs in the 21st century.
To identify shifts in drug discovery leadership.
To assess the impact of national strategies on pharmaceutical innovation.

Main Methods:

Analysis of drug discovery organizational origins.
Tracking the number and sources of new experimental drugs over time.
Comparative assessment of contributions from different countries and sectors.

Main Results:

A significant increase in the overall number of new experimental drugs over the past 25 years.
China has emerged as a major player, now matching US contributions in new drug discovery.
This growth in China reflects coordinated public and private sector efforts.

Conclusions:

The rise of China signifies a major shift in global pharmaceutical R&D leadership.
Future pharmaceutical enterprise decision-making and leadership will be influenced by these changes.
International collaboration and competition dynamics in drug discovery are transforming.