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Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Antibiotic Development: Lessons from the Past and Future Opportunities
Michael S Kinch1, Zachary Kraft2, Tyler Schwartz2
1Center for Research Innovation in Biotechnology, Long Island University, Brookville, NY, 11548, USA. michael.kinch@liu.edu.
Pharmaceutical Research
|April 1, 2024
Summary
Antimicrobial resistance is a growing threat, yet private sector investment in new antibacterial drugs has remained stagnant. Few companies are developing these vital medical countermeasures, despite the urgent need.
Area of Science:
- Infectious Diseases
- Drug Development
- Antimicrobial Resistance
Background:
- Antimicrobial resistance (AMR) poses a significant global health challenge.
- The development of new medical countermeasures against bacterial infections is crucial.
Purpose of the Study:
- To assess the progress and trends in the development of antibacterial drugs from 2000 to 2021.
- To compare private sector activity in antibacterial drug development with other areas, such as oncology.
Main Methods:
- Analysis of clinical trial data from 2000 to 2021.
- Evaluation of the number of investigative drugs, their development stages, and the number of involved organizations.
Main Results:
- Private sector interest in oncology surged, while activity in antibacterial development remained stagnant.
- A declining number of organizations are actively involved in developing new antibacterial products.
- Many companies that previously developed antibacterial agents have exited the field.
Conclusions:
- The development of medical countermeasures against bacterial infections is not keeping pace with the growing threat of antimicrobial resistance.
- There is a concerning decline in organizational involvement and product development pipelines for new antibacterial drugs.
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