[Research progress in targeted delivery of inner ear using nanocarriers]

Area of Science:

• Otic drug delivery
• Nanotechnology applications in medicine
• Inner ear disease therapeutics

Background:

• Inner ear diseases, including sensorineural deafness and Meniere's disease, significantly impair quality of life through communication disorders and reduced work efficiency.
• The unique inner ear anatomy and blood-labyrinth barrier present substantial challenges for conventional drug administration methods, limiting therapeutic efficacy.
• Current treatments often fail to achieve satisfactory outcomes due to these delivery obstacles.

Approach:

• This review explores the potential of nanocarriers for targeted drug delivery within the inner ear.
• It examines various types of nanocarriers and their research progress in overcoming inner ear drug delivery limitations.
• The focus is on advancements in nanotechnology for treating inner ear conditions.

Key Points:

• Nanocarriers represent a cutting-edge nanotechnology approach for overcoming inner ear drug delivery barriers.
• Significant research progress has been made in developing targeted nanocarrier systems for the inner ear.
• Various nanocarriers demonstrate potential advantages for treating sensorineural deafness and Meniere's disease.

Conclusions:

• Nanocarrier-based targeted delivery offers a promising strategy for improving therapeutic outcomes in inner ear diseases.
• Further research into nanocarrier advantages, achievements, and limitations is crucial for clinical application.
• This review provides insights for advancing nanomedicine in otic drug delivery and inner ear disease treatment.