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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 9, 2026

Virtual Reality Tools for Assessing Unilateral Spatial Neglect: A Novel Opportunity for Data Collection
07:04

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Published on: March 10, 2021

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Severity-Dependent Interhemispheric White Matter Connectivity Predicts Poststroke Neglect Recovery.

Brigitte C Kaufmann1,2, Manuela Pastore-Wapp2,3, Paolo Bartolomeo1

  • 1Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Paris 75013, France.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|April 2, 2024
PubMed
Summary
This summary is machine-generated.

Stroke survivors with mild spatial neglect recover well if their brain

Keywords:
DTIactivities of daily livingneglect recoveryoutcomestrokewhite matter connectivity

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Area of Science:

  • Neuroscience
  • Neurology
  • Rehabilitation Medicine

Background:

  • Left-sided spatial neglect is a common challenge post-right-hemispheric stroke, impacting recovery.
  • Mechanisms of spatial neglect recovery, especially the contralesional hemisphere's role, are debated.
  • The contralesional hemisphere's involvement may be maladaptive or compensatory.

Purpose of the Study:

  • To investigate the relationship between initial neglect severity, white matter connectivity, and recovery.
  • To explore the role of the intact hemisphere in spatial neglect recovery.
  • To reconcile differing views on the contralesional hemisphere's function in neglect recovery.

Main Methods:

  • Prospective, observational study of 54 right-hemispheric stroke patients.
  • Assessed neglect severity at admission and discharge from neurorehabilitation.
  • Utilized diffusion tensor imaging (DTI) to assess white matter structural connectivity.

Main Results:

  • Initial neglect severity and spared white matter connectivity predict recovery variability.
  • Mildly impaired patients recover well with intact ipsilesional connectivity.
  • Severely impaired patients require intact contralesional and inter-hemispheric connectivity for recovery.

Conclusions:

  • Spatial neglect recovery depends on initial severity and white matter integrity.
  • The contralesional hemisphere's role is context-dependent, not exclusively compensatory.
  • Findings may inform prognostic biomarkers and tailored therapies for stroke patients.