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Progesterone-Only Contraceptive-Induced Ischemic Colitis.

Medha Rajamanuri¹, Meher Garg², Harris Siddiqui¹

¹Southern Illinois University-School of Medicine, Springfield, IL.

ACG Case Reports Journal

|April 3, 2024

Summary

This summary is machine-generated.

Progesterone-only contraceptives may rarely cause ischemic colitis (IC) in young women. This case highlights the need for more research into progesterone

Keywords:

Bowel ischemia Contraceptive side effects Hormonal contraceptives Ischemic colitis Progesterone-only contraceptives

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Area of Science:

Gastroenterology
Vascular Medicine
Pharmacology

Background:

Ischemic colitis (IC) is typically associated with older individuals and atherosclerotic risk factors.
Hormonal contraceptives, particularly estrogen-containing ones, are known risk factors for thromboembolic events.
The specific impact of progesterone on coagulation and mesenteric arteries remains less understood.

Observation:

A rare case of biopsy-confirmed ischemic colitis (IC) occurred in a young, otherwise healthy woman.
The patient presented with abdominal pain and bloody diarrhea.
IC symptoms developed two months after initiating a progesterone-only oral contraceptive.

Findings:

Progesterone-only oral contraceptives, though rare, can be a potential trigger for ischemic colitis in young women.
The case demonstrates a link between progesterone use and the development of IC.
This finding suggests a possible pro-coagulative effect of progesterone impacting mesenteric circulation.

Implications:

Highlights the need for further investigation into the pro-thrombotic potential of progesterone.
Clinicians should consider IC in young women presenting with relevant symptoms, especially those using progesterone-only contraceptives.
Further research is warranted to elucidate the mechanisms by which progesterone may affect mesenteric artery blood flow and coagulation.