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Presynaptic perspective: Axonal transport defects in neurodevelopmental disorders.

Gui-Jing Xiong1, Zu-Hang Sheng1

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Disruptions in axonal transport of presynaptic proteins cause neurodevelopmental disorders. Restoring this transport may offer early therapeutic intervention for synapse formation and maintenance.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Synapse assembly and maturation are crucial for neuronal function.
  • Defects in these processes are linked to neurodevelopmental disorders.
  • Presynaptic proteins synthesized in the soma are transported via axons to synapses.

Approach:

  • This review focuses on the presynaptic role in neurodevelopmental disorders.
  • It examines impaired axonal transport and its impact on synapse assembly and maintenance.
  • Potential therapeutic strategies targeting axonal transport are discussed.

Key Points:

  • Axonal transport is vital for delivering presynaptic cargos to build functional synapses.
  • Mutations in genes encoding the transport machinery are associated with neurodevelopmental disorders.
  • Emerging evidence highlights presynaptic mechanisms in axonal transport defects.

Conclusions:

  • Understanding presynaptic contributions to axonal transport defects broadens the view of neurodevelopmental disorders.
  • Targeting axonal transport may serve as an early therapeutic strategy.