Related Experiment Video
Updated: Jun 29, 2025
10:39
3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
Published on: June 2, 2014
18.2K
Summary
Trigeminal autonomic cephalalgias (TACs) encompass cluster headache, SUNCT, and SUNA. While first-line treatments remain consistent, new options like high-dose prednisone and galcanezumab offer hope for cluster headache patients.
Area of Science:
- Neurology
- Headache Medicine
Background:
- Trigeminal autonomic cephalalgias (TACs) are a group of distinct headache disorders.
- Accurate diagnosis is essential for effective management of these conditions.
Approach:
- This review covers the epidemiology, clinical presentation, differential diagnosis, pathophysiology, and management of cluster headache, SUNCT, and SUNA.
- It highlights established and emerging treatment strategies.
Key Points:
- First-line treatments include oxygen, triptans, and verapamil for cluster headache; lamotrigine for SUNCT/SUNA.
- Emerging treatments for cluster headache involve high-dose prednisone, galcanezumab, and occipital nerve stimulation.
- Advancements in genetic and imaging studies are enhancing the understanding of cluster headache pathophysiology.
Conclusions:
- TACs present with overlapping symptoms, necessitating precise diagnosis.
- New therapeutic avenues are expanding treatment possibilities for TACs, particularly cluster headache.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
485
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
485
01:27Open Angle Glaucoma: Treatment
440
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
440
01:25Glaucoma: Overview
565
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
565
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
162
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
162