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Aggressive precursor B cell ALL of cervix with obstructive uropathy.

Anupama Bahadur¹, Rajlaxmi Mundhra², Poonam Gill¹

¹Obstetrics and Gynaecology, All India Institute of Medical Sciences - Rishikesh, Rishikesh, Uttarakhand, India.

BMJ Case Reports

|April 3, 2024

Summary

This case report details a rare instance of acute lymphoblastic leukaemia (ALL) presenting initially as a cervical mass with obstructive uropathy. The diagnosis of precursor B cell ALL was incidental, highlighting a unique clinical presentation.

Keywords:

Haematology (incl blood transfusion)Obstetrics and gynaecology Oncology

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Isolation of Precursor B-cell Subsets from Umbilical Cord Blood

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Published on: April 16, 2013

Area of Science:

Oncology
Hematology
Gynecologic Oncology

Background:

Acute lymphoblastic leukaemia (ALL) rarely involves the cervix.
Cervical masses are typically neoplastic or inflammatory, rarely presenting as a leukaemic infiltration.

Observation:

A young woman presented with abdominal pain and vaginal bleeding, found to have a large cervical mass and obstructive uropathy.
Incidental diagnosis of CALLA-positive precursor B cell ALL was made via peripheral blood flow cytometry.
Histopathology and immunohistochemistry confirmed B cell ALL involvement in the cervical mass.

Findings:

This case represents an extremely rare initial presentation of precursor B cell ALL.
The cervical leukaemic infiltration mimicked advanced cervical malignancy.
The patient's history lacked typical leukaemic signs and symptoms.

Implications:

Highlights the importance of considering leukaemic infiltration in cervical masses, even without overt leukaemic symptoms.
Underscores the diagnostic challenge when leukaemic involvement presents as a primary cervical neoplasm.
Adds to the sparse literature on cervical leukaemic infiltration, particularly in young women.