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Updated: Jul 27, 2026
10:04
Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
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[Multiple myeloma with IgH::MYC and multiple extramedullary lesions]
Yuto Sasaki1, Satoshi Ichikawa2, Kazuki Sakurai2
1Tohoku University.
Summary
A rare IgH::MYC translocation in multiple myeloma presents challenges but can be managed. Combined therapies, including chemotherapy and radiation, achieved complete remission in a patient with this aggressive form of the disease.
Area of Science:
- Hematology
- Oncology
- Genetics
Background:
- Multiple myeloma is a plasma cell malignancy characterized by genetic abnormalities.
- Extramedullary disease and specific chromosomal translocations can indicate a poorer prognosis.
Observation:
- A patient presented with shoulder pain, osteolysis, and M-proteinemia, indicative of multiple myeloma.
- Genetic analysis revealed a rare solitary IgH::MYC chromosomal translocation, associated with aberrant plasmacytoid cells and extramedullary lesions.
Findings:
- The patient initially responded to the BLd regimen, but extramedullary lesions recurred.
- Subsequent treatment with EPOCH chemotherapy, radiation, and autologous stem cell transplantation led to complete remission, maintained with lenalidomide.
Implications:
- The IgH::MYC translocation may drive high tumor proliferation and aggressive disease.
- Combined therapeutic modalities offer a promising strategy for managing this rare and aggressive multiple myeloma subtype.
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