Related Experiment Video
Updated: Jun 29, 2025

06:31
"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome
Published on: March 24, 2023
2.3K
Elucidating the Cell Surfaceome to Accelerate Cancer Drug Development
1Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York.
Cancer Discovery
|April 4, 2024
Abstract
Summary:
Cell surface proteins represent ideal therapeutic targets because of their accessibility to antibodies, T cell-directed therapies, and radiotherapies, but there are only 25 therapeutically relevant cell surface targets for which cancer therapies are approved in the United States or European Union. This commentary calls for intensified research into mapping the universe of cell surface proteins - the cell surfaceome - in order to accelerate cancer drug development.

