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A Vision for Democratizing Next-Generation Oncology Clinical Trials

Vivek Subbiah1, Denis Horgan2, Ishwaria M Subbiah1,3

  • 1Sarah Cannon Research Institute, Nashville, Tennessee.

Cancer Discovery
|April 4, 2024
PubMed
Abstract

Insights

Oncology clinical trials need reform to improve access to new cancer therapies and increase participant diversity. A collaborative approach is essential to create inclusive, global cancer research initiatives.

Area of Science:

  • Oncology
  • Clinical Trials
  • Health Equity

Background:

  • Significant advancements in cancer treatment have been achieved.
  • The current clinical trial system faces challenges such as limited access to novel therapies.
  • There is a notable lack of diversity among clinical trial participants.

Purpose of the Study:

  • To outline a vision for democratizing oncology clinical trials.
  • To advocate for globally accessible cancer research.
  • To address barriers hindering equitable participation.

Main Methods:

  • Conceptual framework development.
  • Literature review on clinical trial challenges.
  • Stakeholder analysis (researchers, clinicians, patients, policymakers).

Main Results:

  • Identified key challenges in current oncology trial access and diversity.
  • Proposed a collaborative model for inclusive trial design.
  • Highlighted the need for systemic changes in trial conduct.

Conclusions:

  • Transforming complex, exclusive trials into dynamic, inclusive initiatives is crucial.
  • Multisectoral collaboration is necessary for global health equity in cancer research.
  • Achieving democratized oncology trials requires a paradigm shift in research practices.

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