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A novel deep generative model for mRNA vaccine development: Designing 5' UTRs with N1-methyl-pseudouridine

Xiaoshan Tang1, Miaozhe Huo2, Yuting Chen1

  • 1Institute of Systems Genetics, Department of Critical Care Medicine, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610000, China.

Acta Pharmaceutica Sinica. B
|April 4, 2024
PubMed

Keywords:
5′ UTRCOVID-19Machine learningN1-Methyl-pseudouridineSARS-CoV-2Sequence designmRNA designmRNA vaccine

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