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Disorders of the Male Reproductive System

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Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Exploring the One Health Paradigm in Male Breast Cancer.

Kirsty Luo-Yng Tay¹, George Cowan¹, Subarnarekha Chatterji^1,2

¹School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, AB25 2ZD, UK.

Journal of Mammary Gland Biology and Neoplasia

|April 4, 2024

Summary

This summary is machine-generated.

One Health research reveals similarities in male breast cancer between humans, canines, and primates. However, differences in rare cancer types and tumor classification highlight areas for further investigation.

Keywords:

Canines Felines Male breast cancer One health Primates

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Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

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Published on: April 23, 2021

Area of Science:

Comparative oncology
Veterinary medicine
Human oncology

Background:

Understanding cancer patterns across species, especially rare cancers like male breast cancer, is limited.
The One Health approach integrates human and animal healthcare for medical research advancement.
Lack of laboratory models for male breast cancer hinders functional studies.

Purpose of the Study:

To explore the feasibility of applying the One Health paradigm to male breast cancer.
To review spontaneous occurrences and tumor biology of male breast cancer in other species.

Main Methods:

Conducted a narrative review of spontaneous male breast cancer in primates, canines, and felines.
Compared tumor biology, age distribution, biomarker expression, and metastasis patterns.

Main Results:

Spontaneous male breast cancer observed in captive primates and companion canines/felines.
Similarities found in age distribution, biomarker expression, and metastasis between human and animal cases.
Discrepancies noted in triple-negative/inflammatory breast cancer occurrences and histological classification.

Conclusions:

The One Health approach shows potential for studying male breast cancer, with observed parallels in tumor biology.
Species-specific differences in rare cancer subtypes and histology require further research for full One Health integration.
Addressing disparities is crucial for advancing comparative oncology and developing new research models.