Synergistic Antimicrobial Glycyrrhizic Acid-Based Functional Biosensing Composite for Sensitive Glucose Monitoring...

Area of Science:

• Biomaterials Science
• Nanotechnology
• Wound Healing Research

Background:

• Diabetic wound healing is hindered by high blood glucose and bacterial infections.
• There is a need for advanced materials that can address both issues simultaneously.

Purpose of the Study:

• To develop a functional biosensing composite with antibacterial and glucose-responsive properties for diabetic wound healing.
• To synthesize PTIGA-AgNPs conductive composites and evaluate their performance.

Main Methods:

• In situ synthesis of silver nanoparticles (AgNPs) on PTIGA elastomers.
• Characterization of mechanical, self-healing, and antibacterial properties.
• Assembly of a biosensor to assess glucose response sensitivity and stability.
• In vivo evaluation in a diabetic full-thickness skin defect model.

Main Results:

• PTIGA-AgNPs composites exhibited high strain (1800%) and self-healing efficiency (>90%).
• Antibacterial rates against E. coli and S. aureus exceeded 90%.
• The biosensor demonstrated high glucose sensitivity (0.518 mA mm⁻¹ per 10⁻³ m) and a low detection limit (0.08 × 10⁻³ m).
• In vivo studies showed reduced inflammation and promoted skin/granulation tissue regeneration.

Conclusions:

• The developed PTIGA-AgNPs conductive composites offer a promising solution for diabetic wound management.
• The material's combined antibacterial, biosensing, and regenerative capabilities highlight its therapeutic potential.