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Related Concept Videos

Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

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Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
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Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
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Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

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Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
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Barrett Esophagus-I: Introduction01:21

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Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Detergent-Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans.

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Related Experiment Video

Updated: Jun 29, 2025

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
03:23

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

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The Relationship Between Eosinophilic Esophagitis and Immunotherapy.

Bridget E Wilson1, Maria A Sacta2, Benjamin L Wright1

  • 1Division of Allergy, Asthma and Clinical Immunology, Department of Medicine, Mayo Clinic Arizona, 13400 E. Shea Boulevard Scottsdale, AZ 85259, USA; Division of Allergy/Immunology, Phoenix Children's, 1919 E. Thomas Road, Phoenix, AZ 85054, USA.

Immunology and Allergy Clinics of North America
|April 4, 2024
PubMed
Summary

Oral immunotherapy for food allergies can lead to eosinophilic esophagitis. This review examines the association, treatment, and outcomes of this condition, exploring potential links to other immunotherapies.

Keywords:
Adverse effectsAllergy shotsEosinophilEosinophilic gastrointestinal diseaseOral immunotherapy

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Area of Science:

  • Allergy and Immunology
  • Gastroenterology
  • Clinical Therapeutics

Background:

  • Immunotherapy, including oral immunotherapy (OIT), is used for IgE-mediated food allergies.
  • A subset of patients undergoing OIT may develop eosinophilic esophagitis (EoE).
  • Understanding this association is crucial for patient management.

Purpose of the Study:

  • To review the literature on the association between OIT and EoE.
  • To discuss the treatment and outcomes of immunotherapy-induced EoE.
  • To explore potential mechanisms and related immunotherapies.

Main Methods:

  • Literature review of studies examining OIT and EoE.
  • Analysis of treatment strategies and patient outcomes.
  • Discussion of proposed pathophysiological links.

Main Results:

  • OIT for food allergy is associated with the development of EoE in some patients.
  • Management strategies for OIT-induced EoE are discussed.
  • Potential links to aeroallergen sensitivity and other immunotherapy types (SCIT, SLIT) are explored.

Conclusions:

  • The association between OIT and EoE requires careful monitoring and management.
  • Further research into the mechanisms and therapeutic interventions for OIT-induced EoE is warranted.
  • Epicutaneous immunotherapy (EPIT) is an emerging area for investigation.