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Updated: Jun 29, 2025

Production and Detection of Reactive Oxygen Species ROS in Cancers
07:17

Production and Detection of Reactive Oxygen Species ROS in Cancers

Published on: November 21, 2011

70.1K

Roles of reactive oxygen species in inflammation and cancer

Yunfei Yu1, Shengzhuo Liu1, Luchen Yang1

  • 1Department of Urology West China Hospital Sichuan University Chengdu China.

Medcomm
|April 5, 2024
PubMed

Insights

Reactive oxygen species (ROS) are vital in normal cell function and disease. This review explores ROS's dual role in cancer immunity and immunotherapy, highlighting its therapeutic potential.

Area of Science:

  • Biochemistry and Molecular Biology
  • Immunology
  • Oncology

Background:

  • Reactive oxygen species (ROS) are oxygenic metabolites involved in cellular functions.
  • Imbalances in ROS are linked to various diseases, including cancer, where they play a dual role in tumorigenesis and immune response.
  • Understanding ROS is crucial for cancer research and treatment.

Purpose of the Study:

  • To review the production and regulatory network of ROS in normal cells, inflammation, and cancer.
  • To synthesize the impact of ROS on immune cells and cancer immunity.
  • To explore the potential of ROS-modulating agents as cancer immunotherapies.

Main Methods:

  • Literature review and synthesis of existing research on ROS.
  • Analysis of ROS production and its regulatory mechanisms.
  • Examination of ROS effects on immune cells and immunotherapies.

Main Results:

  • ROS have multifaceted roles in physiological and pathological conditions, including cancer.
  • ROS significantly influence the tumor microenvironment and immune cell function.
  • ROS impact the efficacy of current immunotherapies like checkpoint blockade and CAR T-cell therapy.

Conclusions:

  • ROS are critical players in cancer immunity, influencing tumorigenesis and response to therapy.
  • Targeting ROS modulators presents a promising avenue for novel cancer immunotherapies.
  • Further research into ROS-mediated mechanisms is essential for developing personalized cancer treatments.
Keywords:
cancerimmunereactive oxygen speciestreatment

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