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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

142
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
142
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

228
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

242
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
242
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

179
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
179
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

325
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
325

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Related Experiment Video

Updated: Jun 29, 2025

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
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Acute ischemic stroke in tuberculous meningitis.

Yi-Jia Guo1,2,3, Xin-Ling Gan4, Ru-Yun Zhang5

  • 1Beijing Chest Hospital, Capital Medical University, Beijing, China.

Frontiers in Public Health
|April 5, 2024
PubMed
Summary

Acute ischemic stroke (AIS) in tuberculous meningitis (TBM) is predicted by inflammation markers. AIS partially mediates the link between inflammation and long-term functional outcomes in TBM patients.

Keywords:
acute ischemic strokecohort studymediation analysisrisk factortuberculous meningitis

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • The mechanism of stroke in tuberculous meningitis (TBM) is not well understood.
  • Acute ischemic stroke (AIS) is a significant complication in TBM patients.
  • Identifying predictors of AIS and its role in functional disability is crucial.

Purpose of the Study:

  • To investigate predictors of AIS in TBM patients.
  • To determine if AIS mediates the relationship between inflammation markers and functional disability at 90 days.

Main Methods:

  • A cohort of 1,353 TBM patients was observed across five hospitals.
  • Generalized linear mixed models and subgroup analyses identified AIS predictors.
  • Mediation analyses explored the role of AIS in inflammation-related functional outcomes.

Main Results:

  • The incidence of AIS within 30 days of admission was 20.4%.
  • Predictors of AIS included age ≥35, hypertension, diabetes, smoking, meningeal enhancement, and hydrocephalus.
  • AIS mediated 16.98% of the association between meningeal enhancement and functional disability.

Conclusions:

  • Neuroimaging markers of inflammation are significant predictors of AIS in TBM.
  • AIS plays a partial mediating role in the relationship between inflammation and functional outcomes.
  • Targeting inflammation and hydrocephalus may improve functional outcomes in TBM patients.